Model Description Language (MDL): A Standard for Modeling and Simulation

نویسندگان

  • Mike K. Smith
  • Stuart L. Moodie
  • Roberto Bizzotto
  • Eric Blaudez
  • Elisa Borella
  • Letizia Carrara
  • Phylinda Chan
  • Marylore Chenel
  • Emmanuelle Comets
  • Ronald Gieschke
  • Kajsa Harling
  • Lutz Harnisch
  • Niklas Hartung
  • Andrew C. Hooker
  • Mats O. Karlsson
  • Richard Kaye
  • Charlotte Kloft
  • Natallia Kokash
  • Marc Lavielle
  • Giulia Lestini
  • Paolo Magni
  • Andrea Mari
  • France Mentré
  • Chris Muselle
  • Rikard Nordgren
  • Henrik B. Nyberg
  • Zinnia P. Parra‐Guillén
  • Lorenzo Pasotti
  • Niels Rode‐Kristensen
  • Maria L. Sardu
  • Gareth R. Smith
  • Maciej J. Swat
  • Nadia Terranova
  • Gunnar Yngman
  • Florent Yvon
  • Nick Holford
چکیده

• Initialisation of the R console • Exploratory graphical analysis • Parameter estimation with Monolix using SAEM and model evaluation in Xpose • Parameter estimation in NONMEM using FOCE and model evaluation in Xpose • Parameter estimation in WinBUGS using MCMC • Comparison of parameter estimates • Updating parameter estimates in the MDL Parameter Object using MLE values from NONMEM • Performing a Visual Predictive Check (VPC) in PsN • Using MLE values from NONMEM to simulate new observed values using the simulx function in the mlxR package. • Updating parameter estimates with NONMEM and simulx output • Evaluation of study design characteristics using PFIM • Evaluation of study design characteristics using PopED

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عنوان ژورنال:

دوره 6  شماره 

صفحات  -

تاریخ انتشار 2017