Model Description Language (MDL): A Standard for Modeling and Simulation
نویسندگان
چکیده
• Initialisation of the R console • Exploratory graphical analysis • Parameter estimation with Monolix using SAEM and model evaluation in Xpose • Parameter estimation in NONMEM using FOCE and model evaluation in Xpose • Parameter estimation in WinBUGS using MCMC • Comparison of parameter estimates • Updating parameter estimates in the MDL Parameter Object using MLE values from NONMEM • Performing a Visual Predictive Check (VPC) in PsN • Using MLE values from NONMEM to simulate new observed values using the simulx function in the mlxR package. • Updating parameter estimates with NONMEM and simulx output • Evaluation of study design characteristics using PFIM • Evaluation of study design characteristics using PopED
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2017